Na+/K+ Pump
Na+/K+ Pump
This particular pump is of extreme importance in cell biology as other active membrane transport proteins use the sodium gradient in order to import glucose, amino acids and other nutrients into the cell.
Seen above is Na+/K+ATPase, the protein which facilitates active transport of Na+ or K+ across the membrane.
- As we can see above, ATP is hydrolysed creating ADP and causing the addition of phosphorous to the Na+/K+ATPase.
- This change in structure causes the protein to expose three areas that allows the binding of three Na+ ions.
- This then causes the protein to change shape again and the release the Na+ ions due to low affinity for Na+ ions.
- The pump now open to the extracellular space now binds two K+ ions which causes dephosphorylation - which is to say, the loss of phosphorous.
- This loss of phosphorous causes the K+ ions to be released inside the cell, thus returning the protein to its starting state, allowing the process to occur again.
The sodium gradient created by this process enables SGLT1, sodium-glucose transport protein, to import glucose into the gut cells, etc.





