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May 7

Na+/K+ Pump

Na+/K+ Pump

This particular pump is of extreme importance in cell biology as other active membrane transport proteins use the sodium gradient in order to import glucose, amino acids and other nutrients into the cell.

Seen above is Na+/K+ATPase, the protein which facilitates active transport of Na+ or K+ across the membrane.

File:Scheme sodium-potassium pump-en.svg

  • As we can see above, ATP is hydrolysed creating ADP and causing the addition of phosphorous to the Na+/K+ATPase. 
  • This change in structure causes the protein to expose three areas that allows the binding of three Na+ ions. 
  • This then causes the protein to change shape again and the release the Na+ ions due to low affinity for Na+ ions.
  • The pump now open to the extracellular space now binds two K+ ions which causes dephosphorylation - which is to say, the loss of phosphorous. 
  • This loss of phosphorous causes the K+ ions to be released inside the cell, thus returning the protein to its starting state, allowing the process to occur again.

The sodium gradient created by this process enables SGLT1, sodium-glucose transport protein, to import glucose into the gut cells, etc.

May 5
the-absolute-funniest-posts:

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When a picky question tests the one random factoid I bothered to remember.


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Apr 5
To Protect the World from DevastationTo unite all people within our nationTo denounce the evils of truth and loveTo extend our reach to the stars aboveJessie!James!Team Rocket blast off at the speed of lightSurrender now or prepare to fightMeowth: thats right!

To Protect the World from Devastation
To unite all people within our nation
To denounce the evils of truth and love
To extend our reach to the stars above
Jessie!
James!
Team Rocket blast off at the speed of light
Surrender now or prepare to fight
Meowth: thats right!

Apr 2

That amazing moment when your teacher asks you to go and give something to another teacher

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Taking as slow as possible to get there and get back.


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